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Abstract: 

People with HIV take a combination of HIV medications to reduce the amount of virus they have in their body. When taken as prescribed, these medications, collectively called antiretroviral therapy, can reduce the amount of virus in the body to undetectable levels. Antiretroviral therapy must be taken daily so the virus is less likely to mutate and become resistant to the drugs. Constant exposure to the virus can push killer T cells into a state of exhaustion in which they don’t work as well. The author describe their work combining an HIV vaccine with immunotherapy, which generated robust anti-viral response in multiple parts of the body, including immune-privileged sites in the lymph nodes, and allowed killer T cells to infiltrate and purge viral reservoirs.

Keywords: HIV Vaccination and Immunotherapy

Affiliations:  1: Emory University; 2: Emory University; 3: Emory University.